Surgery Plus HIPEC Only ‘Potential for Cure’ of Peritoneal Mesothelioma

Surgery Plus HIPEC Only ‘Potential for Cure’ of Peritoneal Mesothelioma

In the case of peritoneal mesothelioma, one of the best treatment options is the combination of heated chemotherapy and cytoreductive surgery. Heated chemotherapy is called hyperthermic intraperitoneal chemotherapy (HIPEC).  A study published in the February 2018 has shown the value of this therapy for treating asbestos-related cancer. In this study, the researchers in the United Kingdom analyzed the 9.5 years of data on the patients of peritoneal mesothelioma that were treated with HIPEC and CRS.

The results of this study show that the combination of the CRS and HIPEC is very beneficial for the patients of both malignant and low-grade mesothelioma and it still has the best potential for cure.

Using CRS and HIPEC Together For Mesothelioma Treatment

Peritoneal mesothelioma has less than 20 percent of all mesothelioma diagnosis cases worldwide. Peritoneal mesothelioma is a disease that affects the lining of the abdomen. The treatment for peritoneal mesothelioma is similar to the other asbestos-related cancers. For most patients the combination of the following treatments is very promising:

HIPEC (Hyperthermic Intraperitoneal Chemotherapy)

In this treatment, a concentrated heated mesothelioma chemotherapy treatment is placed into the abdomen during the surgery. With this form of treatment, chemotherapy is directly delivered to the cancer cells in the infected area.

CRS (Cytoreductive Surgery)

This is a form of debulking surgery in which the doctor removes as much of the tumor as possible. In this surgery, the doctors try to remove all visible cancer with curative intent.

Categories of Peritoneal Mesothelioma

There are two types of peritoneal mesothelioma. One is called low-grade peritoneal mesothelioma and the other is called malignant peritoneal mesothelioma. The first category includes well-differentiated papillary mesothelioma and the cell-type multicystic mesothelioma.

In the second type of the mesothelioma, the tumors tend to be more aggressive and include biphasic, epithelioid and sarcomatoid subtypes.

 

Surgery Plus HIPEC is a Powerful Combination

The researchers have found the combination of the HIPEC and surgery very effective in low-grade mesothelioma. After the successful and complete cytoreduction of patients, a 100% overall survival rate is observed with low-grade peritoneal mesothelioma. Although it is not able to cure the more aggressive type of peritoneal mesothelioma it is effective in the low-grade form of peritoneal mesothelioma.

Treatments and Outcomes

In the study, there were patients that ranged in age from 21 to 73 from which 45 percent were female. About half of these patients had the low-grade disease and the other half had diffuse malignant peritoneal mesothelioma. The 26 percent of the patients had tumor debunk which means that nearly all of the tumor was removed, but not 100% of the visible tumor. The other sixty-eight percent of patients had complete tumor removal.

The remaining patients just had biopsies for the diagnosis of the tumor. Of which, 88 percent of patients with low-grade peritoneal mesothelioma that were treated with HIPEC were still alive by the end of the study. If we consider both aggressive and low-grade peritoneal mesothelioma the survival rate was about five years. Average survival rate was 97.8 months which is about 8 years, this timeframe which includes people living with the disease after it recurs.

Who We Are

For over Forty Years the mesothelioma cancer attorneys at GPW have represented thousands of mesothelioma & asbestos exposure victims nationwide. We understand victims of asbestos exposure like no other, thats why we provide them the GPW Advantage. The GPW advantage includes having our professional team of dedicated paralegals & mesothelioma attorneys spend numerous hours investigating your case to get you or your loved one the best possible financial compensation for their case. Our mesothelioma law firm does not earn money unless you do and we are on call 24/7 to help you. If you or your loved one has been recently diagnosed with mesothelioma, do not be reluctant to call us & get the GPW Advantage. For those looking for a New York Mesothelioma Lawyer, Maryland Mesothelioma Lawyer, Florida Mesothelioma lawyer or simply America’s leading mesothelioma lawyer, we can help you.

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Immunotherapy Found Most Effective in Men

Immunotherapy Found Most Effective in Men

Immunotherapy found most effective in men and is available in multiple clinical trials: https://www.cancerresearch.org/patients/clinical-trials. It is a treatment process being used for mesothelioma patients and doctors are constantly researching it. They are trying to find the best way to treat cancer through immunotherapy.

A recent study conducted has shown that immunotherapy is most effective in men as compared to women. Moreover, it does not mean that it is not effective for women, but has been found immunotherapy is most effective in men . This is really an impressive new way to treat cancer that can change the cancer treatment standards. It is better to learn how this treatment works and how it how it can help to treat mesothelioma.

Recent Study on Immunotherapy

Lancet Oncology has recently published a review and analysis of the new high-quality immunotherapy clinical trials. The common question of interest was, “Is there a difference in how well women and men with cancer respond to a type of immunotherapy?”

If the samples are larger, then the researchers are able to uncover differences between the groups. In the case of the Lancet Oncology review, the sample groups were men and women who received immunotherapy. 

How Women and Men Respond to Immunotherapy

Researchers want to understand if there is a difference in the efficiency of immune checkpoint inhibitors between women and men. They want to study the overall survival rate of female and male participants. The review has included 20 high-quality inhibitors. The control trials of four immune checkpoint inhibitors:

• Tremelimumab
• Opdivo
• Keytruda
• Yervoy

All of the 20 studies included 11,351 people with solid cancer. From 11,351, 33 percent were women and sixty-seven percent of participants were men. Of which 63 percent of the people in the studies had lung cancer or melanoma. Men who received checkpoint inhibitors had 28 percent less risk of dying compared to those men who did not receive these drugs. On the other hand, 14 percent of women had less risk of passing away as compared to those women who did not receive the drugs.
The difference shows a clear response rate to immune checkpoint among men compared to women. The study shows that all the patients received benefit from the immune checkpoint inhibitors, but the response rate was higher in men as compared to women.

Should women be considered for immunotherapy?

According to Dr. Omar Abdel-Rahman, “Female patients who are otherwise indicated for treatment with any immune checkpoint inhibitor should not be denied treatment solely on the basis of these findings.”

The women with advanced cancer did not seem to get any benefit from the immune checkpoint inhibitors as compared to men.

How to Get the Most Out of Immunotherapy

Cancer care has recently arranged an hour education workshop with a panel of immunotherapy experts.

In the first part, they have presented an overview of the immunotherapy.

The second part was exclusively focused on the side effects of the immunotherapy.

They have discussed the difference between the chemotherapy and immunotherapy and also its side effect and how to address these side effects on the well-being of the patient. Immunotherapy found most effective in men but this does not mean treatment for Women should be negated as a viable option.

Who We Are

Goldberg, Persky & White P.C. has been at the forefront of complex mesothelioma & asbestos litigation for over forty years. We have the nations leading Maryland mesothelioma lawyer, florida mesothelioma lawyer, New York Mesothelioma lawyer, and best mesothelioma lawyer ready to help you now. Stage 4 mesothelioma cancer symptoms are critical to understand for anyone diagnosed with mesothelioma in the United States.

 

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